However, to our knowledge, no scientific study of the anti-hyperlipidemic effect of the Pandanus tectorius fruit has been reported. A GC—MS method was used to determine the cholesterol as well as coprostanol levels in bile, liver and feces.
Hall et al. Along these lines, Westerterp-Plantenga [ 26 ] found a significant increase in h satiety in subjects consuming a high-protein diet compared to a high-fat diet.
The close relationship between hyperlipidemia and cardiovascular diseases CVD has been well documented . The high-fat diet increased concentrations of total cholesterol, low-density lipoprotein, and total glycerides in the control rats as compared to the normal rats, whereas highdensity lipoprotein decreased in the control rats.
We know that cholesterol excretion from the liver to the bile is collectively controlled by various factors. Mechanisms of satiation with a short-term high-protein diet Sustained satiety is a key component to induce a negative energy balance and to promote weight loss. This observation, however, was independent of Trp concentrations.
A similar phenomenon of appetite suppression can be observed at high altitude where oxygen is limited [ 27 ]. Therefore, modulating the dysregulation of lipid metabolism and decreasing the elevated levels of serum TC, TG and LDL-c are considered to be quite beneficial for the treatment and prevention of CVD .
The research was conducted in accordance with all guidelines and ethics of the Mechanism hyperlipidemia by high fat diet Council on Animal Care.
Diepvens et al. Several factors contribute to increased protein-induced satiety in response to a short-term high-protein intake. The effect of a high-protein diet on body composition and weight loss High-protein diets can help preserve lean body mass during weight loss.
J Ethnopharmacol— It is derived from the ratio between the amount mg of digestible dietary indispensable amino acid in 1 g of the dietary protein and the amount mg of the same dietary indispensable amino acid in 1g of the reference protein. The increase in DIT may increase satiety.
CrossRef Google Scholar Lee M, Kim C, and Kim Y Green tea - -epigallocatechingallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. This satiating effect is most significant after high-protein diets [ 8 ]. According to Nefti et al.
An ideal weight loss strategy would promote satiety and maintain basal metabolic rates despite a negative energy balance and reduction in fat-free mass. The two statins and all coumarins lowered cholesterol and increased high-density lipoprotein level to those of the normal rats.
But unfortunately, most of these drugs generally have side or toxic effects, such as statin-induced myopathy and fibrate-induced rhabdomyolysis [ 67 ]. A study in humans by Blom et al. The aminostatic hypothesis has been supported by several, but not all studies [ 57 ], showing that high-protein diets result in higher levels of satiety, however, complex homeostatic mechanisms between the peripheral organs and the central nervous system which cause the aminostatic effect are not yet fully understood.
Satiety is multifactorial and influenced by many components including but not limited to the endocrine system, the cognitive and neural system as well as the gastrointestinal system.
Bioorg Med Chem Lett 20, — The hamsters that were fed the HFD were then randomly allocated into five groups: Clin Colon Rectal Surg 4 4— Table S2: These differences between the proteins seem to be related to timing and certain amino acid threshold levels. GIP contributes to the regulation of glucose uptake and stimulates triglyceride storage in adipocytes [ 40 ].
Increased incretin levels mediate postprandial insulin release, thereby inducing satiety [ 44 ] and the preference for food-related cues [ 45 ]. PCA was applied to identify outliers and detect data grouping or separation trends, and it also produced an overview of the data set.
J Nutr— The fifteen caffeoylquinic acids present in the PTF-b consisted of four caffeoylquinic acids 1-O-caffeoylquinic acid, 3-O-caffeoylquinic acid, 4-O-caffeoylquinic acid, and 5-O-caffeoylquinic acideight di-O-caffeoylquinic acids 1, 3-di-O-caffeoylquinic acid, 1, 4-di-O-caffeoylquinic acid, 1, 5-di-O-caffeoylquinic acid, 3, 4-di-O-caffeoylquinic acid, 3, 5-di-O-caffeoylquinic acid, 4, 5-di-O-caffeoylquinic acid, 1, 3-di-O-caffeoyl-epi-quinic acid, and 3, 5-di-O-caffeoyl-epi-quinic acidtwo methyl esters of di-O-caffeoylquinic acids methyl 1, 3-di-O-caffeoyl quinate and methyl 3, 4-di-O-caffeoyl quinateand one tri-O-caffeoylquinic acid 3, 4, 5-tri-O-caffeoyl quinate.
The process of gastric emptying might play an important role in the perception of hunger and satiety. Int J Cancer 6E—E Mice fed a high-fat diet rejected their heart transplants faster than mice fed a lower-fat diet.
Yang, L. By using models that mimic the health conditions found in human transplant recipients, the researchers from Tufts determined that transplant rejection was accelerated whether the hyperlipidemia high cholesterol and high triglycerides in the blood was caused by genetics or solely by a high-fat diet.Previous studies showed that high-fat diet-induced hypercholesterolemia triggered mandibular osteoporosis in mice, which was indicated by decreased BV/TV, Tb.N, lawsonforstatesenate.com, and elevated lawsonforstatesenate.com, suggesting that hyperlipidemia impaired bone microstructure and lawsonforstatesenate.com by: 1.
· The main components of Schisandra are lignans, and many research has shown that Schisandra chinensis lignans (SCL) has obvious anti-hyperlipidemia effect, such as reduced hepatic TG and TC levels, in mice with hypercholesterolemia produced by high-fat diet (HFD) containing cholesterol/bile salt, but the therapeutic mechanism was still unclear [11 – 13].Cited by: 6.
high-fat diet (HFD), OCA showed no effect on plasma TC level or LDL-C levels but caused a small increase in HDL-C (23). In contrast to the lack of effect in reduction of plasma HDL-C inCited by: 6. Hyperlipidemia occurs very often in modern society along with a high calorie intake and is regarded as one of the greatest risk factors for the prevalence of cardiac vascular disease (CVD).
· Hyperlipidemia is considered to be one of the greatest risk factors contributing to the prevalence and severity of cardiovascular diseases. In this work, we investigated the anti-hyperlipidemic effect and potential mechanism of action of the Pandanus tectorius fruit extract in hamsters fed a high fat-diet Cited by: However, the mechanism of action is not well understood.
This study was conducted to determine the effect and mechanism of action of mangiferin on hyperlipidemia induced in hamsters by a high-fat diet.
METHODS AND RESULTS: Forty male hamsters were randomly assigned to normal control, high-fat control, and high fat with mangiferin (50 and mg/kg BW) groups. Mangiferin treatment Cited by: